Sunday, April 24, 2011

Nanoparticles Target Cancer Cells


By: Abby VanFossen







Sandia National Labarotories, the University of New Mexico and the UNM Cancer Research and Treatment Center have developed a method of introducing cancer killing drugs through silica nanoparticles directly to cancerous cells. These Nanoparticles are able to store large amounts and varieties of chemicals within their honeycomb shape.





The particles are described as having a nanoporous core with a high surface area and an encapsulating lipid bi-layer (liposome). The nanoparticles and the surrounding cell-like membranes formed from liposomes together become the combination referred to as a protocell: the membrane seals in the deadly cargo and is modified with molecules (peptides) that bind specifically to receptors overexpressed on the cancer cell's surface. (Too many receptors is one signal the cell is cancererous.) The nanoparticles provide stability to the supported membrane and contain and release the therapeutic cargo within the cell. The lipids also serve as a shield that restricts toxic chemotherapy drugs from leaking from the nanoparticle until the protocell binds to and takes hold within the cancer cell. This means that few poisons leak into the system of the human host, if the protocells find no cancer cells. This cloaking mitigates toxic side effects expected from conventional chemotherapy.



This method is currently being tested on human cells in vivo (occurring or carried out in a living organism) and will shortly be tested in mouse tumors. Estimates are that this method will be 10,000 times more effective than current liposome delivery methods and may be available in as early as 5 years. This will be the first work to show targetted delivery of nanoparticles to cancers supported in part by a grant from the National Cancer Institute's Alliance for Nanotechnology in Cancer .(1)



This method provides hope for easier treatment of some cancers. As well, the specific targetting that is being attempted will reduce the side effects of cancer treating drugs in the patient. This may lead to better long term health for the cancer survivor as well as less painful treatments.









1. Carlee E. Ashley, Eric C. Carnes, Genevieve K. Phillips, David Padilla, Paul N. Durfee, Page A. Brown, Tracey N. Hanna, Juewen Liu, Brandy Phillips, Mark B. Carter, Nick J. Carroll, Xingmao Jiang, Darren R. Dunphy, Cheryl L. Willman, Dimiter N. Petsev, Deborah G. Evans, Atul N. Parikh, Bryce Chackerian, Walker Wharton, David S. Peabody, C. Jeffrey Brinker. The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nature Materials, 2011


1 comment:

  1. I am so Happy to be writing this article in here, i am here to explore blogs forum about the wonderful and most safe cure for HERPES SIMPLEX VIRUS . I was positive to the deadly Virus called HERPES and i lost hope completely because i was rejected even by my closet friends. i searched online to know and inquire about cure for HERPES and i saw Dr Ekpiku testimony online on how he was cured so many persons from Herpes Disease so i decided to contact the great herbalist because i know that nature has the power to heal everything. i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 4 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! its really like a dream but i'm so happy! that’s the reason i decided to also add more comment of Him so that more can be saved just like me! and if you need his help,contact his Email now (ekpikuspellhomeofgrace@hotmail.com) or (ekpikuspellhomeofgrace@gmail.com) him on whatsApp number:+2348073673757 or text/call me 16506538578....

    ReplyDelete